Version 5.4
Mus musculus Protein: Atn1
Summary
InnateDB Protein IDBP-539435.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atn1
Protein Name atrophin 1
Synonyms Atr1; atrophin-1; Drpla;
Species Mus musculus
Ensembl Protein ENSMUSP00000115407
InnateDB Gene IDBG-187718 (Atn1)
Protein Structure
UniProt Annotation
Function Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. {ECO:0000250, ECO:0000269PubMed:16702404, ECO:0000269PubMed:19131340}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cell junction {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Most abundant in the brain. {ECO:0000269PubMed:9070948}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 90 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0050827 toxin receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0009404 toxin metabolic process
GO:0016477 cell migration
GO:0030011 maintenance of cell polarity
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0030054 cell junction
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:104725
InterPro IPR002951 Atrophin-like
IPR017993 Atrophin-1
PFAM PF03154
PRINTS PR01222
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35126
PhosphoSite PhosphoSite-O35126
TrEMBL D3YYE6
UniProt Splice Variant
Entrez Gene 13498
UniGene Mm.488648
RefSeq
MGI ID
MGI Symbol Atn1
OMIM
CCDS CCDS20526
HPRD
IMGT
EMBL AC002397 AC164157 BC050920 BC053051 CH466523 D87744
GenPept AAC36003 AAH50920 AAH53051 BAA13450 EDK99754 EDK99755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca