InnateDB Protein
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IDBP-539478.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Osgep
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Protein Name
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O-sialoglycoprotein endopeptidase
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Synonyms
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1500019L24Rik; GCPL-1; PRSMG1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125155
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InnateDB Gene
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IDBG-156792 (Osgep)
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Protein Structure
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Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255HAMAP-Rule:MF_03180}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03180}. Nucleus {ECO:0000255HAMAP-Rule:MF_03180}.
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Disease Associations |
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Tissue Specificity |
Widely expressed at low level. Expressed at intermediate level in lung. Weakly expressed in testis, skeletal muscle, kidney, liver, spleen, brain and heart. {ECO:0000269PubMed:12200116}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
32 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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GO:0046872
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metal ion binding
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Biological Process |
GO:0070526
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threonylcarbamoyladenosine biosynthetic process
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Cellular Component |
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PDB ID |
MGI:1913496
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InterPro |
IPR000905
Gcp-like domain
IPR017861
Kae1/YgjD family
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PFAM |
PF00814
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PRINTS |
PR00789
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BWU5
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PhosphoSite |
PhosphoSite-Q8BWU5
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TrEMBL |
E9QMF4
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UniProt Splice Variant |
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Entrez Gene |
66246
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UniGene |
Mm.274791
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RefSeq |
XP_006519437
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MGI ID |
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MGI Symbol |
Osgep
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OMIM |
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CCDS |
CCDS27026
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HPRD |
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IMGT |
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EMBL |
AC027184
AK049955
BC002296
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GenPept |
AAH02296
BAC34005
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