InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Als2

Summary

InnateDB Protein

IDBP-539529.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Als2

Protein Name

amyotrophic lateral sclerosis 2 (juvenile) homolog (human)

Synonyms

3222402C23Rik; 9430073A21Rik; Als2cr6; Alsin; mKIAA1563;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125753

InnateDB Gene

IDBG-157987 (Als2)

Protein Structure

UniProt Annotation

Function

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity
GO:0017137	Rab GTPase binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042803	protein homodimerization activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001662	behavioral fear response
GO:0001881	receptor recycling
GO:0006979	response to oxidative stress
GO:0007528	neuromuscular junction development
GO:0007626	locomotory behavior
GO:0008104	protein localization
GO:0016050	vesicle organization
GO:0016197	endosomal transport
GO:0032313	regulation of Rab GTPase activity
GO:0032314	regulation of Rac GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035249	synaptic transmission, glutamatergic
GO:0045860	positive regulation of protein kinase activity
GO:0048812	neuron projection morphogenesis
GO:0051036	regulation of endosome size
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005813	centrosome
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0030027	lamellipodium
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031982	vesicle
GO:0043197	dendritic spine
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1921268

InterPro

IPR000219 Dbl homology (DH) domain
IPR000408 Regulator of chromosome condensation, RCC1
IPR003123 Vacuolar sorting protein 9
IPR003409 MORN motif
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PFAM

PF00621
PF00415
PF02204
PF02493

PRINTS

PR00633

PIRSF

SMART

SM00325
SM00698

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt