Mus musculus Protein: Ube2k | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-539575.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ube2k | ||||||||||||||||||||||
Protein Name | ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) | ||||||||||||||||||||||
Synonyms | AW492011; D5Ertd601e; E2-25k; Hip2; Hypg; Lig; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000122471 | ||||||||||||||||||||||
InnateDB Gene | IDBG-166759 (Ube2k) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. Involved in stabilization of CASP12 during ER stress-mediated beta-amyloid neurotoxicity probably by inhibiting proteasome activity; in vitro ubiquitinates CASP12. {ECO:0000269PubMed:18710920}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in the brain, with highest levels found in the mitral cells of the olfactory bulb, the pyramidal cell layer of the hippocampus and the Purkinje cells of the cerebellar cortex. {ECO:0000269PubMed:10585161}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1858216 | ||||||||||||||||||||||
InterPro |
IPR000449
Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal IPR000608 Ubiquitin-conjugating enzyme, E2 IPR009060 UBA-like IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote IPR016135 Ubiquitin-conjugating enzyme/RWD-like |
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PFAM |
PF00627
PF00179 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00165
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P61087 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P61087 | ||||||||||||||||||||||
TrEMBL | Q6ZWQ6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 53323 | ||||||||||||||||||||||
UniGene | Mm.457136 | ||||||||||||||||||||||
RefSeq | NP_058066 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Ube2k | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS39098 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB011081 AK006316 AK031055 AK035371 AK036068 AK048194 AK139564 AK160728 AK162142 BC002013 BC085311 CH466524 | ||||||||||||||||||||||
GenPept | AAH02013 AAH85311 BAA24927 BAB24523 BAC29296 BAC33269 BAE24065 BAE35973 BAE36750 BAE43275 BAE43292 EDL37749 | ||||||||||||||||||||||