InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc11a2

Summary

InnateDB Protein

IDBP-539657.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc11a2

Protein Name

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

Synonyms

DCT1; DMT1; mk; Nramp2; van;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119056

InnateDB Gene

IDBG-184534 (Slc11a2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005375	copper ion transmembrane transporter activity
GO:0005381	iron ion transmembrane transporter activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0005385	zinc ion transmembrane transporter activity
GO:0005506	iron ion binding
GO:0005507	copper ion binding
GO:0008270	zinc ion binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0015086	cadmium ion transmembrane transporter activity
GO:0015087	cobalt ion transmembrane transporter activity
GO:0015093	ferrous iron transmembrane transporter activity
GO:0015094	lead ion transmembrane transporter activity
GO:0015099	nickel cation transmembrane transporter activity
GO:0015100	vanadium ion transmembrane transporter activity
GO:0015295	solute:proton symporter activity
GO:0016151	nickel cation binding
GO:0030145	manganese ion binding
GO:0046870	cadmium ion binding
GO:0050897	cobalt ion binding

Biological Process

GO:0003032	detection of oxygen
GO:0006778	porphyrin-containing compound metabolic process
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006810	transport
GO:0006824	cobalt ion transport
GO:0006826	iron ion transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007611	learning or memory
GO:0010042	response to manganese ion
GO:0010288	response to lead ion
GO:0015676	vanadium ion transport
GO:0015684	ferrous iron transport
GO:0015692	lead ion transport
GO:0015992	proton transport
GO:0034599	cellular response to oxidative stress
GO:0035434	copper ion transmembrane transport
GO:0035444	nickel cation transmembrane transport
GO:0046686	response to cadmium ion
GO:0048813	dendrite morphogenesis
GO:0048821	erythrocyte development
GO:0060586	multicellular organismal iron ion homeostasis
GO:0070574	cadmium ion transmembrane transport
GO:0070627	ferrous iron import
GO:0071281	cellular response to iron ion
GO:0071356	cellular response to tumor necrosis factor
GO:0071421	manganese ion transmembrane transport
GO:0071456	cellular response to hypoxia
GO:0071577	zinc ion transmembrane transport
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005769	early endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0009986	cell surface
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0031902	late endosome membrane
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070826	paraferritin complex

Protein Structure and Domains

PDB ID

MGI:1345279

InterPro

IPR001046 Natural resistance-associated macrophage like

PFAM

PF01566

PRINTS

PR00447

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z314

UniProt Splice Variant

Entrez Gene

18174

UniGene

Mm.415770

RefSeq

MGI ID

MGI Symbol

Slc11a2

OMIM

CCDS

HPRD

IMGT

EMBL

AC139571

GenPept