InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc1a3

Summary

InnateDB Protein

IDBP-539748.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc1a3

Protein Name

solute carrier family 1 (glial high affinity glutamate transporter), member 3

Synonyms

AI504299; B430115D02Rik; Eaat1; GLAST; GLAST-1; GLU-T; GluT-1; Gmt1; MGluT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118902

InnateDB Gene

IDBG-128770 (Slc1a3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005314	high-affinity glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0016595	glutamate binding
GO:0016597	amino acid binding
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006536	glutamate metabolic process
GO:0006537	glutamate biosynthetic process
GO:0006835	dicarboxylic acid transport
GO:0007605	sensory perception of sound
GO:0009416	response to light stimulus
GO:0009449	gamma-aminobutyric acid biosynthetic process
GO:0009611	response to wounding
GO:0010035	response to inorganic substance
GO:0015813	L-glutamate transport
GO:0021545	cranial nerve development
GO:0031223	auditory behavior
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0046677	response to antibiotic
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050806	positive regulation of synaptic transmission
GO:0050885	neuromuscular process controlling balance
GO:0051938	L-glutamate import

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043205	fibril

Protein Structure and Domains

PDB ID

MGI:99917

InterPro

IPR001991 Sodium:dicarboxylate symporter

PFAM

PF00375

PRINTS

PR00173

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YY51

UniProt Splice Variant

Entrez Gene

20512

UniGene

Mm.473285

RefSeq

MGI ID

MGI Symbol

Slc1a3

OMIM

CCDS

HPRD

IMGT

EMBL

AC132899 AC158565

GenPept