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InnateDB Protein
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IDBP-539778.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C1d
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Protein Name
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C1D nuclear receptor co-repressor
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Synonyms
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1110036E10Rik; AI875855; SUN-CoR;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000121134
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InnateDB Gene
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IDBG-152088 (C1d)
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Protein Structure
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| Function |
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=EXOSC10 is required for nucleolar localization. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Kidney, heart, brain, spleen, lung, testis, liver and small intestine. {ECO:0000269PubMed:9405624}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
14 [view]
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| PDB ID |
MGI:1927354
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| InterPro |
IPR007146
Sas10/Utp3/C1D
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| PFAM |
PF04000
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
57316
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| UniGene |
Mm.473933
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
C1d
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4