InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amot

Summary

InnateDB Protein

IDBP-539797.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amot

Protein Name

angiomotin

Synonyms

CAG-2; D0Kist1; Sii6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120226

InnateDB Gene

IDBG-177341 (Amot)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0043532	angiostatin binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0003365	establishment of cell polarity involved in ameboidal cell migration
GO:0006935	chemotaxis
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0034260	negative regulation of GTPase activity
GO:0034613	cellular protein localization
GO:0035329	hippo signaling
GO:0040019	positive regulation of embryonic development
GO:0042074	cell migration involved in gastrulation
GO:0043116	negative regulation of vascular permeability
GO:0043534	blood vessel endothelial cell migration
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0048514	blood vessel morphogenesis
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0005884	actin filament
GO:0005923	tight junction
GO:0008180	COP9 signalosome
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:108440

InterPro

IPR009053 Prefoldin
IPR009114 Angiomotin

PFAM

PRINTS

PR01807

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AXE9

UniProt Splice Variant

Entrez Gene

27494

UniGene

Mm.397273

RefSeq

MGI ID

MGI Symbol

Amot

OMIM

CCDS

HPRD

IMGT

EMBL

AL807753

GenPept