InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abhd5

Summary

InnateDB Protein

IDBP-539908.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abhd5

Protein Name

abhydrolase domain containing 5

Synonyms

1300003D03Rik; 2010002J10Rik; CDS; CGI-58; IECN5; NCIE2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122274

InnateDB Gene

IDBG-205933 (Abhd5)

Protein Structure

UniProt Annotation

Function

Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. {ECO:0000269PubMed:16679289}.

Subcellular Localization

Cytoplasm. Lipid droplet. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.

Disease Associations

Tissue Specificity

Highly expressed in the adipose tissue and testes. Weakly expressed in the liver, muscle, kidney, and heart. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and hypothalamus in brain (at protein level). {ECO:0000269PubMed:15292255, ECO:0000269PubMed:16679289, ECO:0000269PubMed:18832586}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042171	lysophosphatidic acid acyltransferase activity

Biological Process

GO:0006508	proteolysis
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0010891	negative regulation of sequestering of triglyceride
GO:0010898	positive regulation of triglyceride catabolic process
GO:0030154	cell differentiation
GO:0051006	positive regulation of lipoprotein lipase activity