InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HEG1

Summary

InnateDB Protein

IDBP-53999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HEG1

Protein Name

HEG homolog 1 (zebrafish)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311502

InnateDB Gene

IDBG-53997 (HEG1)

Protein Structure

UniProt Annotation

Function

Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001885	endothelial cell development
GO:0001886	endothelial cell morphogenesis
GO:0001944	vasculature development
GO:0001945	lymph vessel development
GO:0003017	lymph circulation
GO:0003209	cardiac atrium morphogenesis
GO:0003281	ventricular septum development
GO:0007043	cell-cell junction assembly
GO:0007507	heart development
GO:0009791	post-embryonic development
GO:0030324	lung development
GO:0035264	multicellular organism growth
GO:0045216	cell-cell junction organization
GO:0048845	venous blood vessel morphogenesis
GO:0050878	regulation of body fluid levels
GO:0060039	pericardium development

Cellular Component

GO:0005576	extracellular region
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane