InnateDB Protein
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IDBP-540032.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nlrp5
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Protein Name
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NLR family, pyrin domain containing 5
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Synonyms
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Mater; Nalp5; Op1; PAN11;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122007
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InnateDB Gene
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IDBG-153886 (Nlrp5)
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Protein Structure
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Function |
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000269PubMed:11062459, ECO:0000269PubMed:18804437}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:14670992}. Nucleus, nucleolus {ECO:0000269PubMed:14670992}. Cytoplasm {ECO:0000269PubMed:14670992}. Note=Located in mitochondria and nucleoli in primary follicle oocytes. Not detected in oocyte mitochondria in type 2 follicles. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.
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Disease Associations |
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Tissue Specificity |
Oocyte-specific. {ECO:0000269PubMed:10433232}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1345193
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InterPro |
IPR003590
Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111
NACHT nucleoside triphosphatase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00368
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R1M5
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PhosphoSite |
PhosphoSite-Q9R1M5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23968
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UniGene |
Mm.420946
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RefSeq |
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MGI ID |
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MGI Symbol |
Nlrp5
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF074018
AF143559
AF143560
AF143561
AF143562
AF143563
AF143564
AF143565
AF143566
AF143567
AF143568
AF143569
AF143570
AF143571
AF143572
AF143573
AK135731
AY196361
AY196362
AY329484
AY329485
AY329486
AY329487
AY329488
AY329489
AY329490
AY329491
BC053384
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GenPept |
AAD51762
AAF64393
AAH53384
AAO52697
AAO52698
AAQ94607
AAQ94608
AAQ94609
AAQ94610
AAQ94611
AAQ94612
AAQ94613
AAQ94614
BAE22633
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