InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERF

Summary

InnateDB Protein

IDBP-54005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERF

Protein Name

Ets2 repressor factor

Synonyms

CRS4; PE-2; PE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000222329

InnateDB Gene

IDBG-54003 (ERF)

Protein Structure

UniProt Annotation

Function

Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Craniosynostosis 4 (CRS4) [MIM:600775]: A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability. {ECO:0000269PubMed:23354439}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highest levels in testis, ovary, pancreas, and heart. {ECO:0000269PubMed:9192842}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0010668	ectodermal cell differentiation
GO:0030154	cell differentiation
GO:0060707	trophoblast giant cell differentiation
GO:0060710	chorio-allantoic fusion