Mus musculus Protein: Lrrtm4
Summary
InnateDB Protein IDBP-540057.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrtm4
Protein Name leucine rich repeat transmembrane neuronal 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000117263
InnateDB Gene IDBG-158745 (Lrrtm4)
Protein Structure
UniProt Annotation
Function May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly in the brain (at protein level). Also expressed in the cerebellum and other tissues. {ECO:0000269PubMed:12676565, ECO:0000269PubMed:22632720}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0072578 neurotransmitter-gated ion channel clustering
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:1901629 regulation of presynaptic membrane organization
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2389180
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80XG9
PhosphoSite PhosphoSite-Q80XG9
TrEMBL
UniProt Splice Variant
Entrez Gene 243499
UniGene Mm.94135
RefSeq NP_001128215
MGI ID
MGI Symbol Lrrtm4
OMIM
CCDS CCDS71778
HPRD
IMGT
EMBL AK032470 AY182031 BC037216
GenPept AAH37216 AAO67552 BAC27887