Version 5.4
Homo sapiens Protein: ZNF300
Summary
InnateDB Protein IDBP-54014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF300
Protein Name zinc finger protein 300
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000274599
InnateDB Gene IDBG-54012 (ZNF300)
Protein Structure
UniProt Annotation
Function Has a transcriptional repressor activity. {ECO:0000269PubMed:14746915}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14746915, ECO:0000269PubMed:23665872}.
Disease Associations
Tissue Specificity Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly expressed in testis. {ECO:0000269PubMed:14746915, ECO:0000269PubMed:17541838}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RE9
PhosphoSite PhosphoSite-Q96RE9
TrEMBL
UniProt Splice Variant
Entrez Gene 91975
UniGene Hs.134885
RefSeq NP_443092
HUGO HGNC:13091
OMIM 612429
CCDS CCDS4311
HPRD 15764
IMGT
EMBL AC010441 AF395541 AK096465 AK300528 BC117248 CH471062 CR933727 DB094933 DQ908918
GenPept AAI17249 AAK83888 ABI81769 BAG53297 BAG62240 CAI46270 EAW61702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca