InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rdh11

Summary

InnateDB Protein

IDBP-540144.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rdh11

Protein Name

retinol dehydrogenase 11

Synonyms

2610319N22Rik; AI428145; Arsdr1; AU045252; C85936; CGI-82; HCBP12; M42C60; Mdt1; Psdr1; SCALD; Ube-1c; UBE-1c1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124066

InnateDB Gene

IDBG-152796 (Rdh11)

Protein Structure

UniProt Annotation

Function

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent all-trans-retinal reductase. Also involved in the metabolism of short-chain aldehydes.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at higher level in liver and testis. Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the outer segment of rods and cones.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0050662	coenzyme binding
GO:0052650	NADP-retinol dehydrogenase activity

Biological Process

GO:0008152	metabolic process
GO:0016062	adaptation of rhodopsin mediated signaling
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0044237	cellular metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:102581

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR013968 Polyketide synthase, KR

PFAM

PF01370
PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt