Version 5.4
Homo sapiens Protein: SERTAD2
Summary
InnateDB Protein IDBP-54017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERTAD2
Protein Name SERTA domain containing 2
Synonyms Sei-2; TRIP-Br2;
Species Homo sapiens
Ensembl Protein ENSP00000326933
InnateDB Gene IDBG-54015 (SERTAD2)
Protein Structure
UniProt Annotation
Function Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F- target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269PubMed:11331592}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18316374}. Cytoplasm {ECO:0000269PubMed:18316374}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
Disease Associations
Tissue Specificity Expressed in adipose tissue. {ECO:0000269PubMed:23291629}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0030308 negative regulation of cell growth
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009263 SERTA domain
PFAM PF06031
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14140
PhosphoSite PhosphoSite-Q14140
TrEMBL
UniProt Splice Variant
Entrez Gene 9792
UniGene Hs.714498
RefSeq NP_055570
HUGO HGNC:30784
OMIM
CCDS CCDS33210
HPRD 18040
IMGT
EMBL AC007365 BC074788 BC074789 BC101639 BC101641 D50917
GenPept AAH74788 AAH74789 AAI01640 AAI01642 AAY14766 BAA09476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca