Version 5.4
Mus musculus Protein: Arpp21
Summary
InnateDB Protein IDBP-540382.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpp21
Protein Name cyclic AMP-regulated phosphoprotein, 21
Synonyms 0710001E13Rik; AI853636; ARPP-21; D9Bwg1012e; R3hdm3; Tarpp;
Species Mus musculus
Ensembl Protein ENSMUSP00000124502
InnateDB Gene IDBG-202918 (Arpp21)
Protein Structure
UniProt Annotation
Function Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000269PubMed:15499021}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11298339, ECO:0000269PubMed:15096520}.
Disease Associations
Tissue Specificity Isoform 1 is present at high levels in thymus and low levels in brain. In thymus, isoform 1 is specifically found in immature thymocytes (at protein level). {ECO:0000269PubMed:11298339}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0005516 calmodulin binding
Biological Process
GO:0034605 cellular response to heat
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:107562
InterPro IPR001374 Single-stranded nucleic acid binding R3H
PFAM PF01424
PRINTS
PIRSF
SMART SM00393
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DCB4
PhosphoSite PhosphoSite-Q9DCB4
TrEMBL E0CYS3
UniProt Splice Variant
Entrez Gene 74100
UniGene Mm.488784
RefSeq XP_006512409
MGI ID
MGI Symbol Arpp21
OMIM
CCDS CCDS23587
HPRD
IMGT
EMBL AC100550 AC130551 AF324451 AK002950 AK029467 AK032417 AK032543 AK045507 AK050613 AK137974 BC027107 BC053001 BC128376
GenPept AAH27107 AAH53001 AAK48713 BAC26463 BAC27859 BAC27918 BAC32399 BAC34343 BAE23526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca