InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mthfr

Summary

InnateDB Protein

IDBP-540384.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mthfr

Protein Name

5,10-methylenetetrahydrofolate reductase

Synonyms

AI323986;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117095

InnateDB Gene

IDBG-204083 (Mthfr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004489	methylenetetrahydrofolate reductase (NADPH) activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0072341	modified amino acid binding

Biological Process

GO:0001666	response to hypoxia
GO:0006555	methionine metabolic process
GO:0009086	methionine biosynthetic process
GO:0033274	response to vitamin B2
GO:0035999	tetrahydrofolate interconversion
GO:0042493	response to drug
GO:0046500	S-adenosylmethionine metabolic process
GO:0050667	homocysteine metabolic process
GO:0051593	response to folic acid
GO:0055114	oxidation-reduction process
GO:0070555	response to interleukin-1

Cellular Component

GO:0005829	cytosol
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:106639

InterPro

IPR003171 Methylenetetrahydrofolate reductase
IPR004621 Eukaryotic-type methylenetetrahydrofolate reductase
IPR029041 FAD-linked oxidoreductase-like

PFAM

PF02219

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AF105988 AF105989 AF105990 AF105991 AF105992 AF105993 AF105994 AF105995 AF105996 AF105997 AF105998 AF404272 AF404274 AK030192 AK043144 AL606929 BC051017 BC052466 BC100550 CH466594

GenPept

AAD20313 AAH51017 AAH52466 AAI00551 AAN40874 AAN40876 BAC26832 BAE43318 CAM14896 EDL14794 EDL14796 EDL14797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca