Version 5.4
Mus musculus Protein: Fcgr2b
Summary
InnateDB Protein IDBP-540388.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcgr2b
Protein Name Fc receptor, IgG, low affinity IIb
Synonyms AI528646; CD32; F630109E10Rik; Fc[g]RII; Fcgr2; Fcgr2a; FcgRII; Fcr-2; Fcr-3; fcRII; Ly-17; Ly-m20; LyM-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000123774
InnateDB Gene IDBG-203935 (Fcgr2b)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0001811 negative regulation of type I hypersensitivity
GO:0002638 negative regulation of immunoglobulin production
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006911 phagocytosis, engulfment
GO:0006952 defense response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0009617 response to bacterium
GO:0016064 immunoglobulin mediated immune response
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030889 negative regulation of B cell proliferation
GO:0032693 negative regulation of interleukin-10 production
GO:0035556 intracellular signal transduction
GO:0050765 negative regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050777 negative regulation of immune response
GO:0071219 cellular response to molecule of bacterial origin
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95499
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL P97918
UniProt Splice Variant
Entrez Gene 14130
UniGene Mm.425062
RefSeq
MGI ID
MGI Symbol Fcgr2b
OMIM
CCDS
HPRD
IMGT
EMBL AC115959 M14277
GenPept AAA37606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca