Version 5.4
Homo sapiens Protein: GPX3
Summary
InnateDB Protein IDBP-54046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX3
Protein Name glutathione peroxidase 3 (plasma)
Synonyms GPx-P; GSHPx-3; GSHPx-P;
Species Homo sapiens
Ensembl Protein ENSP00000373477
InnateDB Gene IDBG-54044 (GPX3)
Protein Structure
UniProt Annotation
Function Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0008134 transcription factor binding
GO:0008430 selenium binding
Biological Process
GO:0006979 response to oxidative stress
GO:0006982 response to lipid hydroperoxide
GO:0042744 hydrogen peroxide catabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000889 Glutathione peroxidase
IPR012336 Thioredoxin-like fold
PFAM PF00255
PF13098
PF13192
PF13462
PF13905
PRINTS PR01011
PIRSF PIRSF000303
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22352
PhosphoSite PhosphoSite-P22352
TrEMBL Q6NXQ3
UniProt Splice Variant
Entrez Gene 2878
UniGene Hs.725787
RefSeq NP_002075
HUGO HGNC:4555
OMIM 138321
CCDS CCDS43389
HPRD 11750
IMGT
EMBL AC008641 AF217787 AY310878 BC013601 BC035841 BC050378 BC066949 D00632 D16360 D16361 D16362 X58295
GenPept AAF43005 AAH13601 AAH35841 AAH50378 AAH66949 AAP50261 BAA00525 BAA03862 BAA03863 BAA03864 CAA41228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca