Version 5.4
Mus musculus Protein: Clec4a2
Summary
InnateDB Protein IDBP-540470.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec4a2
Protein Name C-type lectin domain family 4, member a2
Synonyms Clec4a; Clecsf6; DCIR; Dcir1;
Species Mus musculus
Ensembl Protein ENSMUSP00000124615
InnateDB Gene IDBG-186181 (Clec4a2)
Protein Structure
UniProt Annotation
Function May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000250, ECO:0000269PubMed:11841542}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in splenic antigen-presenting cells including B-cells, monocytes/macrophages, and dendritic cells (at protein level). Expressed in spleen and lymph node and slightly increased with dendritic cell maturation. {ECO:0000269PubMed:11841542}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1349412
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZ15
PhosphoSite PhosphoSite-Q9QZ15
TrEMBL E0CYQ6
UniProt Splice Variant
Entrez Gene 26888
UniGene
RefSeq NP_001163803
MGI ID
MGI Symbol Clec4a2
OMIM
CCDS CCDS20510
HPRD
IMGT
EMBL AC164111 AF387099 AJ133533 AK049002 BC075729 BC096565
GenPept AAH75729 AAH96565 AAM22402 BAC33509 CAB57870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca