InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif26b

Summary

InnateDB Protein

IDBP-540516.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif26b

Protein Name

kinesin family member 26B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124462

InnateDB Gene

IDBG-206875 (Kif26b)

Protein Structure

UniProt Annotation

Function

Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules. {ECO:0000269PubMed:20439720, ECO:0000269PubMed:22768111}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20439720}. Cytoplasm, cytoskeleton {ECO:0000305PubMed:20439720}.

Disease Associations

Tissue Specificity

In newborn kidney, specifically expressed in the mesenchyme. {ECO:0000269PubMed:20439720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0022409	positive regulation of cell-cell adhesion
GO:0030010	establishment of cell polarity
GO:0072092	ureteric bud invasion