Version 5.4
Mus musculus Protein: Reps1
Summary
InnateDB Protein IDBP-540556.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Reps1
Protein Name RalBP1 associated Eps domain containing protein
Synonyms BB161292;
Species Mus musculus
Ensembl Protein ENSMUSP00000123238
InnateDB Gene IDBG-135050 (Reps1)
Protein Structure
UniProt Annotation
Function May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.
Subcellular Localization Membrane, clathrin-coated pit {ECO:0000250}. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in all tissues examined. The highest level expression was found in the kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006898 receptor-mediated endocytosis
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
Protein Structure and Domains
PDB ID MGI:1196373
InterPro IPR000261 EPS15 homology (EH)
IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00027
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54916
PhosphoSite PhosphoSite-O54916
TrEMBL
UniProt Splice Variant
Entrez Gene 19707
UniGene Mm.4479
RefSeq NP_033074
MGI ID 1FI6
MGI Symbol Reps1
OMIM
CCDS CCDS23710
HPRD
IMGT
EMBL AC153433 AF031939 AK041967 AK150284 AK151309 BC002256 BC087547
GenPept AAB94736 AAH87547 BAC31117 BAE29439 BAE30291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca