InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ggnbp1

Summary

InnateDB Protein

IDBP-540595.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ggnbp1

Protein Name

gametogenetin binding protein 1

Synonyms

0610031G08Rik; mdf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115777

InnateDB Gene

IDBG-156124 (Ggnbp1)

Protein Structure

UniProt Annotation

Function

Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis. {ECO:0000269PubMed:19208545}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Mitochondrion intermembrane space.

Disease Associations

Tissue Specificity

Testis-specific. In the testis, expressed only in germ cells and not in somatic cells. Expression starts in late primary spermatocytes in stage X-XII tubules and gradually increases towards step 1-3 spermatids in stage I-III tubules. Expression then declines continuously and disappears after step 7 spermatids in stage VII tubules (at protein level). {ECO:0000269PubMed:19208545}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000266	mitochondrial fission
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation

Cellular Component

GO:0005758	mitochondrial intermembrane space
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:3055306

InterPro

IPR029071 Ubiquitin-related domain

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6K1E7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

70772

UniGene

Mm.482919

RefSeq

MGI ID

MGI Symbol

Ggnbp1

OMIM

CCDS

CCDS28559

HPRD

IMGT

EMBL

AB250379 AK077129 AY141192 BC049764 CH466606

GenPept

AAH49764 AAN10253 BAC36632 BAH22703 EDL22529