InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zscan4c

Summary

InnateDB Protein

IDBP-540736.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zscan4c

Protein Name

zinc finger and SCAN domain containing 4C

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118506

InnateDB Gene

IDBG-142802 (Zscan4c)

Protein Structure

UniProt Annotation

Function

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells. {ECO:0000269PubMed:17553482, ECO:0000269PubMed:19350676, ECO:0000269PubMed:20336070}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00187, ECO:0000269PubMed:20336070}. Chromosome, telomere {ECO:0000269PubMed:20336070}.

Disease Associations

Tissue Specificity

Embryonic stem (ES) cell-specific. Expressed in only 5% of ES cells at a given time, but nearly all ES cells express it at least once during 9 passages. {ECO:0000269PubMed:17553482, ECO:0000269PubMed:20336070}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010833	telomere maintenance via telomere lengthening
GO:0045950	negative regulation of mitotic recombination
GO:0048863	stem cell differentiation