InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timp2

Summary

InnateDB Protein

IDBP-540786.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timp2

Protein Name

tissue inhibitor of metalloproteinase 2

Synonyms

D11Bwg1104e; Timp-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122642

InnateDB Gene

IDBG-214632 (Timp2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008191	metalloendopeptidase inhibitor activity

Biological Process

GO:0007417	central nervous system development
GO:0007568	aging
GO:0008285	negative regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0030814	regulation of cAMP metabolic process
GO:0032487	regulation of Rap protein signal transduction
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043408	regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045861	negative regulation of proteolysis
GO:0045930	negative regulation of mitotic cell cycle
GO:0046580	negative regulation of Ras protein signal transduction
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0030426	growth cone
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:98753

InterPro

IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM

PF00965

PRINTS

PIRSF

SMART

SM00206

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite