InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Narfl

Summary

InnateDB Protein

IDBP-540908.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Narfl

Protein Name

nuclear prelamin A recognition factor-like

Synonyms

9030612I22Rik; AI504405; PRN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117136

InnateDB Gene

IDBG-152948 (Narfl)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001666	response to hypoxia
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0016226	iron-sulfur cluster assembly
GO:0032364	oxygen homeostasis

Cellular Component

GO:0097361

CIA complex

Protein Structure and Domains

PDB ID

MGI:1914813

InterPro

IPR003149 Iron hydrogenase, small subunit-like
IPR004108 Iron hydrogenase, large subunit, C-terminal
IPR009016 Iron hydrogenase

PFAM

PF02256
PF02906

PRINTS

PIRSF

SMART

SM00902

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TMW6

PhosphoSite

PhosphoSite-Q7TMW6

TrEMBL

UniProt Splice Variant

Entrez Gene

67563

UniGene

Mm.24201

RefSeq

MGI ID

MGI Symbol

Narfl

OMIM

CCDS

HPRD

IMGT

EMBL

AK014038 AK018548 AK043694 AK145408 BC052830

GenPept

AAH52830 BAB29126 BAB31268 BAC31620 BAE26421