Version 5.4
| Mus musculus Protein: Galnt4 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-541071.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Galnt4 | ||||||
| Protein Name | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 | ||||||
| Synonyms | AV011803; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000125315 | ||||||
| InnateDB Gene | IDBG-486165 (Galnt4) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b. | ||||||
| Subcellular Localization | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Highly expressed in sublingual gland, stomach, colon, small intestine and cervix. Expressed at intermediate levels in kidney, ovary, lung and uterus. Weakly expressed in spleen, liver, heart and brain. Not expressed in submandibular and parotid glands, skeletal muscle and testis. {ECO:0000269PubMed:9153242}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:894692 | ||||||
| InterPro |
IPR000772
Ricin B lectin domain IPR001173 Glycosyltransferase 2-like IPR029044 Nucleotide-diphospho-sugar transferases |
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| PFAM |
PF00652
PF14200 PF00535 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00458
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | O08832 | ||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 14426 | ||||||
| UniGene | Mm.471143 | ||||||
| RefSeq | NP_056552 | ||||||
| MGI ID | |||||||
| MGI Symbol | Galnt4 | ||||||
| OMIM | |||||||
| CCDS | CCDS48679 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AK033494 AK148036 AK153253 BC057882 U73819 | ||||||
| GenPept | AAB58301 AAH57882 BAC28317 BAE28303 BAE31844 | ||||||