InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdac6

Summary

InnateDB Protein

IDBP-541090.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac6

Protein Name

histone deacetylase 6

Synonyms

Hd6; Hdac5; mHDA2; Sfc6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123482

InnateDB Gene

IDBG-129835 (Hdac6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 143 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	143 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0042903	tubulin deacetylase activity
GO:0043130	ubiquitin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006476	protein deacetylation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007026	negative regulation of microtubule depolymerization
GO:0016575	histone deacetylation
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043241	protein complex disassembly
GO:0070201	regulation of establishment of protein localization
GO:0070842	aggresome assembly
GO:0070846	Hsp90 deacetylation
GO:0071218	cellular response to misfolded protein
GO:0090042	tubulin deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005881	cytoplasmic microtubule
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1333752

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AUA9

UniProt Splice Variant

Entrez Gene

15185

UniGene

Mm.29854

RefSeq

MGI ID

MGI Symbol

Hdac6

OMIM

CCDS

HPRD

IMGT

EMBL

AL670169

GenPept