Version 5.4
Mus musculus Protein: Bai3
Summary
InnateDB Protein IDBP-541326.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bai3
Protein Name brain-specific angiogenesis inhibitor 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000116231
InnateDB Gene IDBG-139491 (Bai3)
Protein Structure
UniProt Annotation
Function May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0016525 negative regulation of angiogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2441837
InterPro IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR000884 Thrombospondin, type 1 repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497
PFAM PF01825
PF00002
PF00090
PF02793
PF12003
PRINTS PR00249
PR01694
PIRSF
SMART SM00303
SM00209
SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80ZF8
PhosphoSite PhosphoSite-Q80ZF8
TrEMBL Q8BJ13
UniProt Splice Variant
Entrez Gene 210933
UniGene Mm.403760
RefSeq NP_783573
MGI ID
MGI Symbol Bai3
OMIM
CCDS CCDS14855
HPRD
IMGT
EMBL AC116556 AC117221 AC121828 AC122187 AC129314 AC140308 AK044248 AK081421 AY168406 AY255544 CH466536
GenPept AAO27431 AAO85056 BAC31839 BAC38215 EDL14414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca