InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fuom

Summary

InnateDB Protein

IDBP-541399.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fuom

Protein Name

RIKEN cDNA 1810014F10 gene

Synonyms

Fucu; Le51;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120353

InnateDB Gene

IDBG-211657 (Fuom)

Protein Structure

UniProt Annotation

Function

Involved in the interconversion between alpha- and beta- L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O- glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. {ECO:0000269PubMed:17602138}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed in various tissues and cell lines, including kidney, liver, and pancreas, marginally in muscle and testis. {ECO:0000269PubMed:17602138}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016853	isomerase activity
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0042806	fucose binding
GO:0048029	monosaccharide binding

Biological Process

GO:0005996	monosaccharide metabolic process
GO:0006004	fucose metabolic process
GO:0036065	fucosylation
GO:0045665	negative regulation of neuron differentiation
GO:0060180	female mating behavior

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1916314

InterPro

IPR007721 D-ribose pyranase RbsD/L-fucose mutarotase FucU
IPR023750 RbsD-like domain

PFAM

PF05025

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R2K1

PhosphoSite

PhosphoSite-Q8R2K1

TrEMBL

UniProt Splice Variant

Entrez Gene

69064

UniGene

Mm.41915

RefSeq

MGI ID

2WCU

MGI Symbol

Fuom

OMIM

CCDS

HPRD

IMGT

EMBL

AB094480 AK044731 AK079410 AK163708 BC028662

GenPept

AAH28662 BAC32055 BAC37637 BAD11304 BAE37468