InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gga2

Summary

InnateDB Protein

IDBP-541453.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gga2

Protein Name

golgi associated, gamma adaptin ear containing, ARF binding protein 2

Synonyms

1200007E24Rik; mKIAA1080;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115581

InnateDB Gene

IDBG-208808 (Gga2)

Protein Structure

UniProt Annotation

Function

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030306	ADP-ribosylation factor binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005622	intracellular
GO:0005802	trans-Golgi network
GO:0010008	endosome membrane
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle

Protein Structure and Domains

PDB ID

MGI:1921355

InterPro

IPR002014 VHS
IPR004152 GAT
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR008153 Clathrin adaptor, gamma-adaptin, appendage
IPR008942 ENTH/VHS
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR018205 VHS subgroup

PFAM

PF00790
PF03127
PF02883

PRINTS

PIRSF

SMART

SM00809
SM00288

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P5E6