Version 5.4
Mus musculus Protein: Sphkap
Summary
InnateDB Protein IDBP-541695.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sphkap
Protein Name SPHK1 interactor, AKAP domain containing
Synonyms 4930544G21Rik; A930009L15Rik; AI852220; mKIAA1678; SKIP;
Species Mus musculus
Ensembl Protein ENSMUSP00000124384
InnateDB Gene IDBG-174504 (Sphkap)
Protein Structure
UniProt Annotation
Function Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Colocalizes with SPHK1 in the cytoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051018 protein kinase A binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005739 mitochondrion
GO:0030018 Z disc
Protein Structure and Domains
PDB ID MGI:1924879
InterPro IPR018292 A-kinase anchor 110kDa, C-terminal
PFAM PF05716
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NSW3
PhosphoSite PhosphoSite-Q6NSW3
TrEMBL
UniProt Splice Variant
Entrez Gene 77629
UniGene Mm.410097
RefSeq XP_006496638
MGI ID
MGI Symbol Sphkap
OMIM
CCDS
HPRD
IMGT
EMBL AK019735 AK034183 AK038638 AK122538 BC042654 BC060165 BC060217 BC069832
GenPept AAH42654 AAH60165 AAH60217 AAH69832 BAC25605 BAC28620 BAC30075 BAC65820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca