InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phb

Summary

InnateDB Protein

IDBP-541739.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phb

Protein Name

prohibitin

Synonyms

Bap32;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119603

InnateDB Gene

IDBG-209638 (Phb)

Protein Structure

UniProt Annotation

Function

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:11302691}.

Disease Associations

Tissue Specificity

Widely expressed in different tissues. {ECO:0000269PubMed:8070406}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001541	ovarian follicle development
GO:0001552	ovarian follicle atresia
GO:0001649	osteoblast differentiation
GO:0006260	DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0016575	histone deacetylation
GO:0030308	negative regulation of cell growth
GO:0031100	organ regeneration
GO:0034097	response to cytokine
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045471	response to ethanol
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050847	progesterone receptor signaling pathway
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071354	cellular response to interleukin-6
GO:0071897	DNA biosynthetic process
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030061	mitochondrial crista
GO:0031315	extrinsic component of mitochondrial outer membrane
GO:0070062	extracellular vesicular exosome