Version 5.4
Mus musculus Protein: Spcs1
Summary
InnateDB Protein IDBP-541743.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spcs1
Protein Name signal peptidase complex subunit 1 homolog (S. cerevisiae)
Synonyms 1810004F21Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000124428
InnateDB Gene IDBG-144206 (Spcs1)
Protein Structure
UniProt Annotation
Function Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
Subcellular Localization Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0043022 ribosome binding
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0005787 signal peptidase complex
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1916269
InterPro IPR009542 Microsomal signal peptidase 12kDa subunit
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF06645
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D958
PhosphoSite PhosphoSite-Q9D958
TrEMBL
UniProt Splice Variant
Entrez Gene 69019
UniGene
RefSeq
MGI ID
MGI Symbol Spcs1
OMIM
CCDS CCDS26903
HPRD
IMGT
EMBL AK007336 AK082928 BC034270 BC049895
GenPept AAH49895 BAB24969 BAC38696

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca