InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasd2

Summary

InnateDB Protein

IDBP-541863.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasd2

Protein Name

RASD family, member 2

Synonyms

4930526B11Rik; AU045414; Rhes; TEM-2; TEM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120717

InnateDB Gene

IDBG-169069 (Rasd2)

Protein Structure

UniProt Annotation

Function

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. {ECO:0000269PubMed:15199135, ECO:0000269PubMed:18035555}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain; prominently in the striatum and weakly in kidney, thyroid, lung, heart and testis. Not expressed in liver. Expressed in pancreatic cell lines and in a embryonic stem cell line. {ECO:0000269PubMed:15199135, ECO:0000269PubMed:16945334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007626	locomotory behavior
GO:0015031	protein transport
GO:0031397	negative regulation of protein ubiquitination
GO:0033235	positive regulation of protein sumoylation
GO:0043949	regulation of cAMP-mediated signaling
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1922391

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt