InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apex1

Summary

InnateDB Protein

IDBP-541873.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apex1

Protein Name

apurinic/apyrimidinic endonuclease 1

Synonyms

APE; Apex; HAP1; Ref-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123148

InnateDB Gene

IDBG-156891 (Apex1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003713	transcription coactivator activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518	nuclease activity
GO:0004521	endoribonuclease activity
GO:0008081	phosphoric diester hydrolase activity
GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0016491	oxidoreductase activity
GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490	chromatin DNA binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0007568	aging
GO:0014912	negative regulation of smooth muscle cell migration
GO:0042493	response to drug
GO:0043488	regulation of mRNA stability
GO:0045454	cell redox homeostasis
GO:0045739	positive regulation of DNA repair
GO:0055114	oxidation-reduction process
GO:0070301	cellular response to hydrogen peroxide
GO:0071320	cellular response to cAMP
GO:0071375	cellular response to peptide hormone stimulus
GO:0080111	DNA demethylation
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0016607	nuclear speck
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:88042

InterPro

IPR004808 AP endonuclease 1
IPR005135 Endonuclease/exonuclease/phosphatase

PFAM

PF03372
PF14529

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z6R9

UniProt Splice Variant

Entrez Gene

11792

UniGene

Mm.488643

RefSeq

MGI ID

MGI Symbol

Apex1

OMIM

CCDS

HPRD

IMGT

EMBL

AC027184

GenPept