Version 5.4
| Mus musculus Protein: Mfrp | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-541899.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Mfrp | ||||||
| Protein Name | membrane-type frizzled-related protein | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000124456 | ||||||
| InnateDB Gene | IDBG-155695 (Mfrp) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | May play a role in eye development. | ||||||
| Subcellular Localization | Apical cell membrane {ECO:0000269PubMed:17122143}; Single-pass type II membrane protein {ECO:0000269PubMed:17122143}. | ||||||
| Disease Associations | Note=Defects in Mfrp are the cause of retinal degeneration 6 (RD6). RD6 is an autosomal recessive degeneration of the photoreceptors causing dysfunction of both rods and cones. | ||||||
| Tissue Specificity | Expressed in retinal pigment epithelium and ciliary epithelium of the eye. {ECO:0000269PubMed:12140190, ECO:0000269PubMed:17122143}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:2385957 | ||||||
| InterPro |
IPR000859
CUB domain IPR002172 Low-density lipoprotein (LDL) receptor class A repeat IPR020067 Frizzled domain |
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| PFAM |
PF00431
PF00057 PF01392 |
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| PRINTS |
PR00261
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| PIRSF | |||||||
| SMART |
SM00042
SM00192 SM00063 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q8K480 | ||||||
| PhosphoSite | PhosphoSite-Q8K480 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 259172 | ||||||
| UniGene | Mm.227110 | ||||||
| RefSeq | NP_001177243 | ||||||
| MGI ID | |||||||
| MGI Symbol | Mfrp | ||||||
| OMIM | |||||||
| CCDS | CCDS52776 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AF469650 AK053629 | ||||||
| GenPept | AAM89216 BAC35452 | ||||||