Version 5.4
| Mus musculus Protein: Sp100 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Protein | IDBP-541903.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | Sp100 | ||||||||||||||||
| Protein Name | nuclear antigen Sp100 | ||||||||||||||||
| Synonyms | A430075G10Rik; | ||||||||||||||||
| Species | Mus musculus | ||||||||||||||||
| Ensembl Protein | ENSMUSP00000118481 | ||||||||||||||||
| InnateDB Gene | IDBG-175861 (Sp100) | ||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||
| Function | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity). {ECO:0000250}. | ||||||||||||||||
| Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00185, ECO:0000255PROSITE-ProRule:PRU00747}. Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Accumulates in the cytoplasm upon FAS activation. {ECO:0000250}. | ||||||||||||||||
| Disease Associations | |||||||||||||||||
| Tissue Specificity | |||||||||||||||||
| Comments | |||||||||||||||||
| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||
| PDB ID | MGI:109561 | ||||||||||||||||
| InterPro |
IPR000770
SAND domain IPR004865 Sp100 IPR010919 SAND domain-like |
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| PFAM |
PF01342
PF03172 |
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| PRINTS | |||||||||||||||||
| PIRSF | |||||||||||||||||
| SMART |
SM00258
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| TIGRFAMs | |||||||||||||||||
| Post-translational Modifications | |||||||||||||||||
| Modification | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | O35892 | ||||||||||||||||
| PhosphoSite | PhosphoSite-O35892 | ||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 20684 | ||||||||||||||||
| UniGene | Mm.486514 | ||||||||||||||||
| RefSeq | XP_006529343 | ||||||||||||||||
| MGI ID | |||||||||||||||||
| MGI Symbol | Sp100 | ||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | AC147806 AC161342 AF038850 AF040241 AF040242 U83630 U83636 | ||||||||||||||||
| GenPept | AAC40172 AAC40174 AAC53512 AAC53513 | ||||||||||||||||