InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C230052I12Rik

Summary

InnateDB Protein

IDBP-541928.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C230052I12Rik

Protein Name

RIKEN cDNA C230052I12 gene

Synonyms

AW124591; AW538696; Faap24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115766

InnateDB Gene

IDBG-174098 (C230052I12Rik)

Protein Structure

UniProt Annotation

Function

Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding

Biological Process

GO:0006281	DNA repair
GO:0008150	biological_process

Cellular Component

GO:0043240

Fanconi anaemia nuclear complex

Protein Structure and Domains

PDB ID

MGI:2142208

InterPro

IPR010994 RuvA domain 2-like

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BHL6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

101831

UniGene

Mm.389855

RefSeq

MGI ID

MGI Symbol

C230052I12Rik

OMIM

CCDS

CCDS21149

HPRD

IMGT

EMBL

AK031566 AK040248 AK082457 AK166481 BC096687

GenPept

AAH96687 BAC27452 BAC30550 BAC38495 BAE38800