Version 5.4
Mus musculus Protein: Txnl4a
Summary
InnateDB Protein IDBP-541932.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txnl4a
Protein Name thioredoxin-like 4A
Synonyms D18Wsu98e; Dim1; ENSMUSG00000057130; Txnl4; U5-15kD; U5-15kDa;
Species Mus musculus
Ensembl Protein ENSMUSP00000115320
InnateDB Gene IDBG-201727 (Txnl4a)
Protein Structure
UniProt Annotation
Function Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0007067 mitotic nuclear division
GO:0008380 RNA splicing
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005681 spliceosomal complex
Protein Structure and Domains
PDB ID MGI:1351613
InterPro IPR004123 mRNA splicing factor, thioredoxin-like U5 snRNP
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF02966
PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF PIRSF017199
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P83877
PhosphoSite PhosphoSite-
TrEMBL F8WGE7
UniProt Splice Variant
Entrez Gene 27366
UniGene Mm.172411
RefSeq NP_079575
MGI ID
MGI Symbol Txnl4a
OMIM
CCDS CCDS29365
HPRD
IMGT
EMBL AC131065 AK004039 AK007331 AK148287 AK166497 BC031634
GenPept AAH31634 BAB23137 BAB24966 BAE28459 BAE38809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca