Version 5.4
Mus musculus Protein: Cyp2c40
Summary
InnateDB Protein IDBP-542005.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp2c40
Protein Name cytochrome P450, family 2, subfamily c, polypeptide 40
Synonyms AI265721; AI662255;
Species Mus musculus
Ensembl Protein ENSMUSP00000125217
InnateDB Gene IDBG-164135 (Cyp2c40)
Protein Structure
UniProt Annotation
Function Metabolizes arachidonic acid to produce an unidentified metabolite that coelutes with 16-,17-, and 18- hydroxyeicosatetraenoic acid (HETE).
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity Liver, brain, kidney, and intestine, with trace amounts in lung and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1306815
InterPro IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00359
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56657
PhosphoSite PhosphoSite-P56657
TrEMBL E9Q7C8
UniProt Splice Variant
Entrez Gene 13099
UniGene Mm.353875
RefSeq NP_034134
MGI ID
MGI Symbol Cyp2c40
OMIM
CCDS CCDS29798
HPRD
IMGT
EMBL AC121935 AF047727 BC139471 BC139472
GenPept AAD13722 AAI39472 AAI39473

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca