InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dync2h1

Summary

InnateDB Protein

IDBP-542058.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dync2h1

Protein Name

dynein cytoplasmic 2 heavy chain 1

Synonyms

4432416O06Rik; AI448217; b2b414Clo; D030010H02Rik; D330044F14Rik; DHC1b; DHC2; Dnchc2; mKIAA1997;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120007

InnateDB Gene

IDBG-131859 (Dync2h1)

Protein Structure

UniProt Annotation

Function

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells. {ECO:0000269PubMed:16061793, ECO:0000269PubMed:16229832, ECO:0000269PubMed:8666668}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:8666668}. Cell membrane {ECO:0000269PubMed:8666668}; Peripheral membrane protein {ECO:0000269PubMed:8666668}. Cytoplasm {ECO:0000269PubMed:8666668}. Note=Localizes to the apical cytoplasm. According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum.

Disease Associations

Tissue Specificity

Detected in brain, lung, spleen and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level). {ECO:0000269PubMed:11907264, ECO:0000269PubMed:12432068}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007030	Golgi organization
GO:0007368	determination of left/right symmetry
GO:0008105	asymmetric protein localization
GO:0009953	dorsal/ventral pattern formation
GO:0016485	protein processing
GO:0021522	spinal cord motor neuron differentiation
GO:0030182	neuron differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0035721	intraciliary retrograde transport
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0030286	dynein complex
GO:0031512	motile primary cilium
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:107736

InterPro

IPR003593 AAA+ ATPase domain
IPR004273 Dynein heavy chain domain
IPR010978 tRNA-binding arm
IPR011704 ATPase, dynein-related, AAA domain
IPR013594 Dynein heavy chain, domain-1
IPR013602 Dynein heavy chain, domain-2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03028
PF07728
PF08385
PF08393

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q45VK7