InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Comt

Summary

InnateDB Protein

IDBP-542320.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Comt

Protein Name

catechol-O-methyltransferase

Synonyms

Comt1; D16Wsu103e; D330014B15Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121810

InnateDB Gene

IDBG-141739 (Comt)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity

Biological Process

GO:0007565	female pregnancy
GO:0007612	learning
GO:0008210	estrogen metabolic process
GO:0009712	catechol-containing compound metabolic process
GO:0014070	response to organic cyclic compound
GO:0016036	cellular response to phosphate starvation
GO:0032259	methylation
GO:0032496	response to lipopolysaccharide
GO:0042417	dopamine metabolic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0045963	negative regulation of dopamine metabolic process
GO:0048265	response to pain
GO:0048609	multicellular organismal reproductive process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050668	positive regulation of homocysteine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:88470

InterPro

IPR002935 O-methyltransferase, family 3
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01596

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z227

UniProt Splice Variant

Entrez Gene

12846

UniGene

RefSeq

MGI ID

MGI Symbol

Comt

OMIM

CCDS

HPRD

IMGT

EMBL

AC133487

GenPept