InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prodh

Summary

InnateDB Protein

IDBP-542329.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prodh

Protein Name

proline dehydrogenase

Synonyms

Pro-1; Pro1; Ym24d07;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117597

InnateDB Gene

IDBG-141018 (Prodh)

Protein Structure

UniProt Annotation

Function

Converts proline to delta-1-pyrroline-5-carboxylate.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Note=Pro/re mice that have a premature termination on Prodh are sluggish in their movement.

Tissue Specificity

Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004657	proline dehydrogenase activity
GO:0016597	amino acid binding
GO:0071949	FAD binding

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0006562	proline catabolic process
GO:0010133	proline catabolic process to glutamate
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:97770

InterPro

IPR002872 Proline dehydrogenase
IPR029041 FAD-linked oxidoreductase-like

PFAM

PF01619

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WU79

PhosphoSite

PhosphoSite-Q9WU79

TrEMBL

UniProt Splice Variant

Entrez Gene

19125

UniGene

Mm.405088

RefSeq

MGI ID

MGI Symbol

Prodh

OMIM

CCDS

HPRD

IMGT

EMBL

AC087064 AF120279 AK144068 BC125327 CH466521 U80020

GenPept

AAD24776 AAF21467 AAI25328 BAE25683 EDK97501