InnateDB Protein
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IDBP-542346.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Spdya
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Protein Name
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speedy homolog A (Xenopus laevis)
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Synonyms
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4921517J08Rik; 4930548B21Rik; GS4; MLZ-465; Spdy1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000118426
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InnateDB Gene
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IDBG-197047 (Spdya)
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Protein Structure
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Function |
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269PubMed:15611625}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:20339383}.
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Disease Associations |
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Tissue Specificity |
Expressed at a high level in testis. Also expressed in the adult ovary and in immature oocytes. {ECO:0000269PubMed:11730327, ECO:0000269PubMed:15611625, ECO:0000269PubMed:20339383}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0019901
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protein kinase binding
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0007140
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male meiosis
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GO:0007275
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multicellular organismal development
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GO:0008284
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positive regulation of cell proliferation
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GO:0045737
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positive regulation of cyclin-dependent protein serine/threonine kinase activity
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Cellular Component |
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PDB ID |
MGI:1918141
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InterPro |
IPR020984
Cell cycle regulatory protein, Spy1
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PFAM |
PF11357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5IBH7
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PhosphoSite |
PhosphoSite-Q5IBH7
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TrEMBL |
B2RWC8
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UniProt Splice Variant |
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Entrez Gene |
70891
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UniGene |
Mm.477599
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RefSeq |
NP_001136103
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MGI ID |
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MGI Symbol |
Spdya
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OMIM |
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CCDS |
CCDS50179
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HPRD |
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IMGT |
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EMBL |
AK077138
AY820306
AY820307
BC147706
BC147719
CT010429
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GenPept |
AAI47707
AAI47720
AAW32476
AAW32477
BAC36637
CAX16044
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