InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAMK1D

Summary

InnateDB Protein

IDBP-54254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK1D

Protein Name

calcium/calmodulin-dependent protein kinase ID

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368122

InnateDB Gene

IDBG-54250 (CAMK1D)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine- induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269PubMed:11050006, ECO:0000269PubMed:15840691, ECO:0000269PubMed:16324104, ECO:0000269PubMed:17056143}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.

Disease Associations

Tissue Specificity

Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. {ECO:0000269PubMed:11050006, ECO:0000269PubMed:12935886, ECO:0000269PubMed:15840691}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0010976	positive regulation of neuron projection development
GO:0032793	positive regulation of CREB transcription factor activity
GO:0050766	positive regulation of phagocytosis
GO:0050773	regulation of dendrite development
GO:0060267	positive regulation of respiratory burst
GO:0071622	regulation of granulocyte chemotaxis
GO:0090023	positive regulation of neutrophil chemotaxis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005954	calcium- and calmodulin-dependent protein kinase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt