Version 5.4
Mus musculus Protein: Plrg1
Summary
InnateDB Protein IDBP-542557.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plrg1
Protein Name pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
Synonyms AA958940; C80566; Tango4;
Species Mus musculus
Ensembl Protein ENSMUSP00000114968
InnateDB Gene IDBG-154656 (Plrg1)
Protein Structure
UniProt Annotation
Function Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0034504 protein localization to nucleus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1858197
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922V4
PhosphoSite PhosphoSite-Q922V4
TrEMBL F8WI31
UniProt Splice Variant
Entrez Gene 53317
UniGene Mm.286349
RefSeq NP_058064
MGI ID
MGI Symbol Plrg1
OMIM
CCDS CCDS17433
HPRD
IMGT
EMBL AC138394 AF044334 AK075993 AK076007 AK077197 BC006750 BC052895
GenPept AAC04388 AAH06750 BAC36104 BAC36115 BAC36675

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca