InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UPF3A

Summary

InnateDB Protein

IDBP-54257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPF3A

Protein Name

UPF3 regulator of nonsense transcripts homolog A (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364448

InnateDB Gene

IDBG-54255 (UPF3A)

Protein Structure

UniProt Annotation

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269PubMed:11163187, ECO:0000269PubMed:16601204}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269PubMed:11113196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003723	RNA binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006913	nucleocytoplasmic transport
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045727	positive regulation of translation
GO:0051028	mRNA transport