Version 5.4
Mus musculus Protein: 5033414D02Rik
Summary
InnateDB Protein IDBP-542572.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 5033414D02Rik
Protein Name RIKEN cDNA 5033414D02 gene
Synonyms 1110007H22Rik; 5033414D02Rik; AI852040; Plg-R(KT); Plg-RKT;
Species Mus musculus
Ensembl Protein ENSMUSP00000120466
InnateDB Gene IDBG-157201 (5033414D02Rik)
Protein Structure
UniProt Annotation
Function Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9. {ECO:0000269PubMed:19897580, ECO:0000269PubMed:21795689, ECO:0000269PubMed:21940822}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:19897580, ECO:0000269PubMed:21795689}; Multi-pass membrane protein {ECO:0000269PubMed:19897580, ECO:0000269PubMed:21795689}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/Plaur.
Disease Associations
Tissue Specificity Expressed in monocytes; detected in differentiated monocytes but not in progenitor cells. Expressed in adrenal medulla and hippocampus. {ECO:0000269PubMed:21795689}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0010756 positive regulation of plasminogen activation
Cellular Component
GO:0005739 mitochondrion
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1915009
InterPro IPR019319 Protein of unknown function DUF2368
PFAM PF10166
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D3P8
PhosphoSite PhosphoSite-Q9D3P8
TrEMBL D3YXU2
UniProt Splice Variant
Entrez Gene 67759
UniGene Mm.391741
RefSeq NP_080638
MGI ID
MGI Symbol Plgrkt
OMIM
CCDS CCDS29734
HPRD
IMGT
EMBL AC119228 AK017215 AK168454 AK170700 BC024953
GenPept AAH24953 BAB30638 BAE40355 BAE41963

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca